WWW.HATICE.EU

Healthy Aging

Through Internet Counselling

in the Elderly

 

 

Collaborative project co-funded by the European Unions' Seventh Framework Programme (FP7, 2007-2013) under grant agreement No 305374.

flag European Union   logo FP7 Cooperation

 

 

  • M Kivipelto. Advances in the prevention of vascular cognitive impairment, October 2016, VasCog International Congress, Amsterdam, The Netherlands
  • E. Richard. Multimodal Interventions for the Prevention of Dementia. October 2016, National Academy of Sciences, Engineering and Medicine, Washington
  • M Kivipelto. Dementia Prevention among at Risk Persons. September 8th, 2016, IPA (International Psychogeriatric Association) International Congress, San Francisco, CA, USA
  • E. Richard, M. Kivipelto. Dementia Prevention from a population perspective. September 2016, International Psychogeriatric Association, San Francisco
  • E. Richard. Prevention of Dementia by Intensive Vascular Care – a cluster randomized trial. Alzheimer’s Association International Conference,July 2016, Toronto
  • M.Kivipelto. Award lecture on dementia prevention (MetLife Foundation Awards for Medical Research in Alzheimer’s Disease). July 2016, AAIC/Metlife plenary session, Toronto, Canada
  • M.Kivipelto. Multimodal strategies to promote healthy brain aging. June 2016. 23rd Nordic Congress of Gerontology, Tampere, Finland
  • F Mangialasche. Multimodal interventions in prodromal Alzheimer’s disease: creating an innovative research platform. May 2016, Center for Innovative Medicine (CIMED) meeting, Stockholm, Sweden
  • M. Kivipelto, Prevention of dementia – What have we learned from population-based studies. May 2016, Demensdagerne 2016, Copenhagen
  • E. Richard. Prevention of Dementia by Intensive Vascular Care – a cluster randomized trial. May 2016, European Stroke Organisation Conference, Barcelona
  • Meiller Y, Guillemont J, Beishuizen CR, Richard E, Kivipelto M, Andrieu S. An IS Approach for Handling Missing Data in Collaborative Medical Research. Twenty-second Americas Conference on Information Systems; 2016; San Diego.
    pdfdownload
  • Barbera M., Management of vascular and lifestyle-related risk factors for Alzheimer's disease and dementia in older adults: a European perspective. Alzheimer's Association International Conference (AAIC), 2014, Copenhagen, Denmark
  • Mangialasche F., Can dementia be prevented? Results and experiences from Sweden and Finland.  Dementia in Europe: a challenge for our common future conference, 2014, Rome, Italy 
  • Kivipelto M., Preventing cognitive decine with life style interventions. International congres of the European Union Geriatric Medicine Society, 2014, Rotterdam, the Netherlands
  • Kivipelto M., A multi-domain two-year randomized controlled trial to prevent cognitive impairment - the FINGER study. Alzheimer's Association International Conference (AAIC), 2014, Copenhagen, Denmark
  • Andrieu S., Ongoing dementia preventive trials worldwide.2eme Congres Quebecois sur la Maladie d'Alzheimer et Maladies Apparentees, 2014, Quebec, Canada
  • Andrieu S., Non-pharmacological clinical trials to prevent Alzheimer's disease. Clinical Trials on Alzheimer's disease (CTAD) conference, 2014, Philadelphia, USA
  • Brayne C., Population studies of Ageing and the brain in the UK. International Alliance of Research Universities (IARU) conference "Cultures of Health and Aging", 2014, Copenhagen, Denmark
  • Kivipelto M., Can lifestyle choices predict outcome in dementia? 8th World Congress on Controversies in Neurology, Berlin, Germany
  • Richard E., Towards and internet-intervention for prevention of stroke, cardiovascular disease and dementia: sharing data to improve trial design - the HATICE project, European Stroke Conference, Nice, France
  • Kivipelto M.(as advisory board member), Mapping big data for research on dementia and Alzheimer's disease, OECD meeting, Paris, France 
  • Kivipelto M.,Multi-domain intervention studies to prevent dementia and Alzheimer's disease. 13th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy, Geneva, Switzerland 
  • Kivipelto M., Preventing and delaying dementia. Panel discussion with the G8 dementia summit, Global action against dementia, London UK
  • Richard E., Dementia prevention from a public health perspective, G8 dementia summit, Global action against dementia, London UK
  • Andrieu, S., From epidemiological studies to multidomain prevention trials28th International Conference of Alzheimer's Disease 2013, Taipei, Taiwan
  • Andrieu, S., AD prevention: place of The HATICE Project, International Academy Nutrition and Aging Symposium on Nutrition and Physical & Cognitive Frailty 2013, Seoul, Korea
  • Solomon A, T. Ngandu, T. Laatikainen, et al.: Changes is dementia risk factors over 40 years: Experiences from Finland. Alzheimer's Association International Conference 2013, Boston, Massachuset, USA
  • Kivipelto, M., organization of the Paralell session "Multidomain Interventions" 8th International Congress on Vascular dementia, 2013, Athens, Greece
  • Kivipelto, M., From observation to action in dementia prevention: The FINGER study and European Dementia Prevention Initiative.  8th International Congress on Vascular dementia 2013, Athens, Greece
  • Van Gool, W.A., Use of new technology to improve dementia prevention: the Healthy Aging Through Internet Counseling in the Elderly (HATICE) project, 8th International Congress on Vascular dementia, 2013, Athens, Greece
  • Andrieu, S. Participation in dementia prevention studies: experiences from the ACCEPT study8th International Congress on Vascular dementia, 2013, Athens, Greece
  • Ngandu, T., From observation to action in dementia prevention: Lifestyle interventions to prevent Alzheimer's Disease: experiences from the FINGER studyIUSN 20th INternational Congress of Nutrition, 2013, Granada, Spain
  • Ngandu, T., An overview of our current understanding of the prevention of dementia, 23rd Alzheimer Europe Conference 2013, St. Julian's, Malta





 

  • Edo Richard, Eric P Moll van Charante, Marieke P Hoevenaar-Blom, Nicola Coley, Mariagnese Barbera, Abraham van der Groep, Yannick Meiller, Francesca Mangialasche, Cathrien B Beishuizen, Susan Jongstra, Tessa van Middelaar, Lennard L Van Wanrooij, Tiia Ngandu, Juliette Guillemont, Sandrine Andrieu, Carol Brayne, Miia Kivipelto, Hilkka Soininen, Willem A Van Gool. Healthy ageing through internet counselling in the elderly (HATICE). Lancet Digital Health 2019; published online Nov 14.
    https://doi.org/10.1016/S2589-7500(19)30153-0.
    https://www.thelancet.com/journals/landig/article/PIIS2589-7500(19)30194-3/fulltext

  • Hoevenaar-Blom MP, Guillemont J, Ngandu T, Beishuizen CRL, Coley N, Moll van Charante EP, Andrieu S, Kivipelto M, Soininen H, Brayne C, Meiller Y, Richard E. Improving data sharing in research with context-free encoded missing data. PLoS One. 2017 Sep 12;12(9):e0182362.
    PubMed

  • Coley N, Ngandu T, Lehtisalo J, Soininen H, Vellas B, Richard E, Kivipelto M, Andrieu S; HATICE, FINGER, and MAPT/DSA groups. Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials. Alzheimers Dement. 2019 Jun;15(6):729-741.
    PubMed

  • Coley N, Rosenberg A, van Middelaar T, Soulier A, Barbera M, Guillemont J, Steensma J, Igier V, Eskelinen M, Soininen H, Moll van Charante E, Richard E, Kivipelto M, Andrieu S; MIND-AD; HATICE groups. Older Adults' Reasons for Participating in an eHealth Prevention Trial: A Cross-Country, Mixed-Methods Comparison. J Am Med Dir Assoc. 2019 Jul;20(7):843-849.e5. doi: 10.1016/j.jamda.2018.10.019. Epub 2018 Dec 9.
    PubMed

  • Beishuizen CR, Akenine U, Barbera M, Rosenberg A, Fallah Pour M, Richard E, Soininen H, Mangialasche F, Kivipelto M, Pols AJ, Moll van Charante E.Integrating nurses' experiences with supporting behaviour change for cardiovascular prevention into a self-management internet platform in Finland and the Netherlands: a qualitative study. BMJ Open. 2019 Jun 6;9(6):e023480.
    PubMed

  • Barbera M, Mangialasche F, Jongstra S, Guillemont J, Ngandu T, Beishuizen C, Coley N, Brayne C, Andrieu S, Richard E, Soininen H, Kivipelto M; HATICE study group. Designing an Internet-Based Multidomain Intervention for the Prevention of Cardiovascular Disease and Cognitive Impairment in Older Adults: The HATICE Trial. J Alzheimers Dis. 2018;62(2):649-663. doi: 10.3233/JAD-170858.
    PubMed

  • Andrieu S, Guyonnet S, Coley N, Cantet C, Bonnefoy M, Bordes S, Bories L, Cufi MN, Dantoine T, Dartigues JF, Desclaux F, Gabelle A, Gasnier Y, Pesce A, Sudres K, Touchon J, Robert P, Rouaud O, Legrand P, Payoux P, Caubere JP, Weiner M, Carrié I, Ousset PJ, Vellas B; MAPT Study Group. Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial. Lancet Neurol. 2017 Mar 27. pii: S1474-4422(17)30040-6.
    PubMed

  • van Middelaar T, Beishuizen CRL, Guillemont J, Barbera M, Richard E, Moll van Charante EP; HATICE consortium. Engaging older people in an internet platform for cardiovascular risk self-management: a qualitative study among Dutch HATICE participants. BMJ Open. 2018 Jan 21;8(1):e019683.
    PubMed

  • Moll van Charante EP, Richard E, Eurelings LS, van Dalen JW, Ligthart SA, van Bussel EF, Hoevenaar-Blom MP, Vermeulen M, van Gool WA. Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial. Lancet. 2016 Aug 20;388(10046):797-805.
    PubMed

  • Jongstra S, Beishuizen C, Andrieu S, Barbera M, van Dorp M, van de Groep B, Guillemont J, Mangialasche F, van Middelaar T, van Charante EM, Soininen H, Kivipelto M, Richard E. Development and Validation of an Interactive Internet Platform for Older People: The Healthy Ageing Through Internet Counselling in the Elderly Study. Telemed J E Health. 2017 Feb;23(2):96-104.
    PubMed

  • Beishuizen CR, Coley N, Moll van Charante EP, van Gool WA, Richard E, Andrieu S. Determinants of Dropout and Nonadherence in a Dementia Prevention Randomized Controlled Trial: The Prevention of Dementia by Intensive Vascular Care Trial. J Am Geriatr Soc. 2017 Jul;65(7):1505-1513.
    PubMed

  • Edo Richard, Susan Jongstra, Hilkka Soininen, Carol Brayne, Eric P. Moll van Charante, Yannick Meiller, Bram van der Groep, Cathrien R. L. Beishuizen, Francesca Mangialasche, Mariagenese Barbera, Tiia Ngandu, Nicola Coley, Juliette Guillemont, Stéphanie Savy, Marcel G. W. Dijkgraaf, Ron J. G. Peters, Willem A. van Gool, Miia Kivipelto, Sandrine Andrieu. Healthy Ageing Through Internet Counselling in the Elderly: the HATICE randomised controlled trial for the prevention of cardiovascular disease and cognitive impairment. BMJ Open. 2016 Jun 10;6(6):e010806.
    PubMed

  • Beishuizen CR, Stephan BC, van Gool WA, Brayne C, Peters RJ, Andrieu S, Kivipelto M, Soininen H, Busschers WB, Moll van Charante EP, Richard E. Web-Based Interventions Targeting Cardiovascular Risk Factors in Middle-Aged and Older People: A Systematic Review and Meta-Analysis.J Med Internet Res. 2016 Mar 11;18(3):e55.
    PubMed

  • Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015 Mar 11. pii: S0140-6736(15)60461-5.
    PubMed

  • Ligthart SA, van den Eerenbeemt KD, Pols J, van Bussel EF, Richard E, Moll van Charante EP. Perspectives of older people engaging in nurse-led cardiovascular prevention programmes: a qualitative study in primary care in the Netherlands. Br J Gen Pract. 2015 Jan;65(630):e41-8.
    PubMed

  • Ngandu T, Lehtisalo J, Levälahti E, Laatikainen T, Lindström J, Peltonen M, Solomon A, Ahtiluoto S, Antikainen R, Hänninen T, Jula A, Mangialasche F, Paajanen T, Pajala S, Rauramaa R, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. Recruitment and baseline characteristics of participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-a randomized controlled lifestyle trial. Int J Environ Res Public Health. 2014 Sep 10;11(9):9345-60.
    PubMed

  • Solomon A, Mangialasche F, Richard E, Andrieu S, Bennett DA, Breteler M, Fratiglioni L, Hooshmand B, Khachaturian AS, Schneider LS, Skoog I, Kivipelto M. (2014): Advances in the prevention of Alzheimer's disease and dementiaJIM Mar; 275(3):229-50.
    PubMed

  • Kivipelto M, Solomon A, Ahtiluoto S, Ngandu T, Lehtisalo J, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Nissinen A, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H. (2013): The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progressAlzhemers Dement. 9(6), 657-65 
    PubMed

  • Richard E, Andrieu S, Solomon A, Mangialasche F, Ahtiluoto S, Moll van Charante EP, Coley N, Fratiglioni L, Neely AS, Vellas B, van Gool WA, Kivipelto M. (2012): Methodological challenges in designing dementia prevention trials - the European Dementia Prevention Initiative (EDPI). J Neurol Sci. 322(1-2), 64-70.
    PubMed

  • Ngandu T, Lehtisalo J, Levälahti E, Laatikainen T, Lindström J, Peltonen M, Solomon A, Ahtiluoto S, Antikainen R, Hänninen T, Jula A, Mangialasche F, Paajanen T, Pajala S, Rauramaa R, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M (2014): Recruitment and baseline characteristics of participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-a randomized controlled lifestyle trial. Int J Environ Res Public Health;11 (9):9345-60.
    PubMed

  • Richard E, Brayne C (2014): Dementia prevention strategies - beyond the randomised controlled trial. J Prev Alz Dis;2:62-64

  • Richard E, Khachaturiani ES (2014): Multi-Domain Prevention for a Multi-Factorial Disease. J Prev Alz Dis;1:4-5

14-11-2019

Healthy Ageing with an online coach

It turns out older people can improve their lifestyle and adopt healthier behaviours with the support of an online coach. This way they can reduce their risk of cardiovascular disease and dementia. This is reported by an international group of researchers, led by Amsterdam University Medical Centre in the Netherlands, in The Lancet Digital Health today.

In the ‘Healthy Ageing Through Internet Counselling in the Elderly’ (HATICE) project, 2724 persons over 65 years with an increased risk of cardiovascular disease and dementia participated. These participants were from The Netherlands, Finland and France. Half of the participants, the treatment group, was in contact with a coach via the Internet. On a specifically developed website, they could set goals to improve their health and monitor their own progress towards a healthier lifestyle. The focus for improvement was on blood pressure, physical inactivity, overweight, smoking and high cholesterol. The other half, the control group, received access to a website with general health information, without a coach.

After 18 months, 90% of the treatment group set one or more goals related to their lifestyle, with the support of their coach. The researchers investigated the effect on a composite measure for cardiovascular disease risk, including blood pressure, body mass index (BMI) and cholesterol. The research shows that the treatment group had a modest, but significant improvement compared to the control group. This effect was largest in those participants who were most active on the website: for each additional goal set, the score representing the risk of cardiovascular disease improved.

These results are promising, but the researchers stress that prevention requires a long-term effort. Lead investigator Dr. Edo Richard: ‘Although the magnitude of the effect is relatively small, with this type of approach it takes time and larger effects are more likely in people with a higher risk of cardiovascular disease or those with less access to health care, such as people in low- and middle-income countries, but also people with low social advantage in Europe’.

The research also shows, according to co-lead investigator Dr. Eric Moll van Charante, that modern technology in the form of self-management with an online coach can be a valuable addition to regular health care, also in older persons. ’The results invite testing this type of intervention on a larger scale to confirm whether the beneficial effects we see are sustainable over time and eventually lead to fewer heart attacks, strokes and dementia in the long term’.

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