Academic Medical Center Amsterdam

The Department of Neurology at the AMC has a longstanding history of clinical research in several fields including most prominently cognitive disorders and stroke. The department has a very experienced clinical trials bureau employing six full-time research nurses, coordinating several RCTs including the preDIVA-study (n=3533), the Preventive Antibiotics in Stroke Study (PASS, n=3200, recently completed) and the Anti-platelet therapy in combination with Recombinant t-PA thrombolysis in Ischemic Stroke study (ARTIS, n=600, recently completed). There is an excellent collaboration with the Epidemiology and Biostatistics unit. The academic Department of General Practice has a focus on clinical research in geriatric populations and is involved in large epidemiological studies. In close collaboration with the department of Geriatrics at the AMC in 2009 the FIT-study was started. FIT is a cluster-RCT (n=8000) to assess the effect of comprehensive geriatric assessment and coordination by a practice nurse in a primary care setting to retain functional independence and reduce institutionalization among elderly patients with increased risk of functional decline. The collaboration between the departments of neurology, general practice and epidemiology and biostatistics forms an excellent basis for the coordination of HATICE. The current collaboration with 125 GP-practices in PreDIVA forms a strong basis for the proposed RCT in HATICE

Key persons:

Dr. Edo Richard

Edo Richard
Dr. Edo Richard is a neurologist at the department of neurology at the Academic Medical Center in Amsterdam and the Radboud University medical center in Nijmegen. He is mainly involved in research on vascular risk factors and cognitive decline and he combines research with clinical work in general neurology and cognitive disorders. In 2010 he worked as a post-doc at Columbia University Medical Centre in New York, USA (Prof J.A. Luchsinger) to improve his skills in neuro-epidemiology. He is in charge of the multidisciplinary meetings with the departments of geriatrics, neuropsychology and psychiatry at the AMC. He is the PI of the preDIVA-MRI sub-study. In addition, he is scientific advisor for the Dutch Medicines Evaluation Board. Dr. Edo Richard has several PhD students.

Professor Willem A van Gool

willemvangool portrait
Professor Willem A van Gool is a professor of Neurology, especially the dementias, and head of the memory clinic at the department of neurology. For many years combined research with clinical work in general neurology and cognitive disorders. He has been the PI in several RCTs on cognitive decline and dementia in both cognitively intact elderly as well as patients with cognitive decline (NSAIDs in Alzheimer's disease; Evaluation of Vascular care in Alzheimer's disease, EVA; preDIVA). He is the head of the neuropsychiatry research group of the department, and his main lines of research are on vascular factors in dementia, prevention of cognitive decline, and delirium. He is a permanent member of the Scientific Advisory Group Neurology of the European Medicines Agency (EMA), which can be instrumental for the development of the Adverse Event monitoring system developed in WP4 and WP5. As of mid 2012, he was appointed as President of the Health Council of the Netherlands but will remain highly involved in the HATICE research.

Dr. Eric P. Moll van Charante

Eric Moll van Charante
Dr. Eric P. Moll van Charante is a general practitioner who combines clinical work as a GP with an academic career in primary care and public health. He is involved in several large cohort studies and RCTs in primary care, including the mentioned FIT-study of which he is one of the initiators and key investigators. He is the co-PI of the preDIVA study and coordinator for all 125 participating GPs. In addition he is one of the investigators of the CAHE-study. This is a randomised controlled trial to investigate effectiveness of a culturally-appropriate hypertension education (CAHE) by practice nurses for patients with uncontrolled hypertension of African origin in Dutch primary care.

Professor Ron Peters

Ron Peters
Professor Ron Peters is professor of Cardiology, with focus on the prevention and treatment of atherosclerotic heart disease. He has been the PI in several RCT's on antithrombotic treatments of acute coronary syndromes, and on lifestyle interventions following hospitalisation for acute coronary syndromes. He is national coordinator of several international trials on the 'Polypill' approach to primary prevention of cardiovascular disease.

Cathrien Beishuizen

Cathrien Beishuizen
Cathrien Beishuizen is a PhD-student. She will be involved in WP 3, 4 and 6, analysing the collected data of the ongoing trials and using these insights for the design of the new trial.
She graduated in September 2012 as MD at the Faculty of Medicine of the University of Amsterdam. Her main interest is primary health care and public health. She developed this interest when working as a voluntary teaching assistant at the Faculty of Medicine in Beira in Mozambique. There, she taught students about family- and community health and assisted them in preventive health projects. Her first research-experience was during a scientific internship at the Department of Experimental Immunology at the AMC.

Susan Jongstra

foto Susan kleiner
Susan Jongstra is a PhD-student. She graduated as a medical doctor in February 2013 at the Faculty of Medicine of the University of Amsterdam. She also studied psychobiology. During her study period she developed a distinct interest in Neurology. In 2013 she worked as a junior doctor at the Neurology department at a local hospital. Her first research-experience was during a scientific internship at the Karolinska Institutet in Stockholm, Sweden.
She will mainly be involved  in the ongoing trials evaluation, the design of the generic intervention, and the controlled trial itself (WP 3, 4 and 6).

Tessa van Middelaar

Tessa van Middelaar is a PhD-student. She graduated in January 2015 as medical doctor at the Faculty of Medicine of the University of Amsterdam. During her study period she worked on a cohorts study on quality of life in stroke patients and completed the honours-masters programme.

She will mainly be involved in the controlled trial.

Dr. Marieke Hoevenaar-Blom

mariekehoevenaarblom portrait
Dr. Marieke P. Hoevenaar-Blom is epidemiologist with a special interest in preventive cardiology. In 2013 she obtained a PhD-title with her dissertation on ‘Lifestyle factors in association with cardiovascular diseases’. Currently, she works as a post-doc at AMC and project manager of HATICE.

Lennard van Wanrooij

Lennard 4
Lennard van Wanrooij obtained a Master's Degree in Healthcare Psychology in August 2014. He has specific interest in clinical neuropsychology and advanced statistical methods. Prior to the start of his PhD thesis on the HATICE trial, he was part of a study group investigating cognition in Parkinson's Disease at the AMC. Lennard will be involved in several parts of the HATICE project, for example the RCT and the shared data platform.

Carin Miedema

Carin Miedema has extended experience as initiator and coordinator of several studies for the departments of Neurology and General Medicine at the AMC. A recent example was the preDIVA study. For HATICE her main tasks are to connect all involved in the Dutch part of the trial, such as junior and senior investigators, logistic and financial personnel, and participants. This way she ensures good data collection and a smooth running trial.